
| Rank | Film (Distributor) | Daily Gross | Locations | Location Avg. | %Change YD | %Change LW | Total Gross | TG ÷ OW | Week |
| 1 | The Upside (STXfilms) | $2,834,401 | 3,080 | $920 | +61.8% | N/A | $24,941,585 | 1.225 | 1 |
| 2 | Aquaman (Warner Bros.) | $2,268,757 | 3,863 | $587 | +59.6% | -41.1% | $291,638,247 | 4.297 | 4 |
| 3 | Spider-Man: Into the Spider-Verse (Sony / Columbia) | $1,120,509 | 3,029 | $370 | +62.7% | -30.0% | $149,635,115 | 4.231 | 5 |
| 4 | A Dog's Way Home (Sony / Columbia) | $1,112,865 | 3,090 | $360 | +73.8% | N/A | $13,004,322 | 1.156 | 1 |
| 5 | Escape Room (Sony / Columbia) | $1,048,323 | 2,717 | $386 | +48.6% | -41.8% | $34,215,086 | 1.876 | 2 |
| 6 | The Mule (Warner Bros.) | $962,209 | 3,329 | $289 | +59.6% | -28.3% | $92,272,454 | 5.270 | 5 |
| 7 | Bumblebee (Paramount) | $906,051 | 3,303 | $274 | +75.2% | -40.6% | $110,326,701 | 5.095 | 4 |
| 8 | Mary Poppins Returns (Disney) | $877,345 | 3,253 | $270 | +67.9% | -45.6% | $152,492,694 | 6.483 | 4 |
| 9 | On the Basis of Sex (Focus) | $846,590 | 1,923 | $440 | +59.3% | +381.9% | $11,780,612 | 1.941 | 3 |
| 10 | Vice (Annapurna Pictures) | $496,719 | 1,724 | $288 | +47.9% | -49.6% | $36,726,165 | 4.728 | 3 |
| 11 | Bohemian Rhapsody (Fox) | $395,702 | 1,334 | $297 | +38.7% | -20.3% | $199,179,039 | 3.901 | 11 |
| 12 | If Beale Street Could Talk (Annapurna Pictures) | $384,367 | 1,018 | $378 | +61.1% | +36.2% | $8,329,100 | 3.461 | 5 |
| 13 | Green Book (Universal / DreamWorks) | $352,375 | 742 | $475 | +46.3% | -1.6% | $39,201,136 | 7.126 | 9 |
| 14 | Replicas (Entertainment Studios Motion Pictures) | $319,235 | 2,329 | $137 | +51.1% | N/A | $2,905,865 | 1.223 | 1 |
| 15 | Second Act (STXfilms) | $285,832 | 1,681 | $170 | +91.5% | -61.6% | $36,820,133 | 5.673 | 4 |
| 16 | Ralph Breaks the Internet (Disney) | $194,244 | 1,554 | $125 | +40.1% | -41.3% | $190,826,556 | 3.393 | 8 |
| 17 | A Star is Born (Warner Bros.) | $156,188 | 394 | $396 | +29.3% | +102.7% | $203,857,258 | 4.751 | 15 |
| 18 | The Favourite (Fox Searchlight) | $155,310 | 512 | $303 | +32.3% | -51.6% | $21,754,070 | 8.349 | 8 |
| 19 | Mary Queen of Scots (Focus) | $143,290 | 829 | $173 | +45.4% | -52.7% | $15,471,385 | 6.792 | 6 |
| 20 | Holmes & Watson (Sony / Columbia) | $85,093 | 1,013 | $84 | +61.2% | -78.9% | $30,171,619 | 4.071 | 3 |
| 21 | Perfectos Desconocidos (Lionsgate / Pantelion) | $48,877 | 132 | $370 | +65.7% | N/A | $501,031 | 1.185 | 1 |
| 22 | Creed II (MGM) | $37,545 | 355 | $106 | +42.8% | -63.9% | $114,949,888 | 3.231 | 8 |
| 23 | Fantastic Beasts: The Crimes of Grindelwald (Warner Bros.) | $35,843 | 275 | $130 | +55.4% | -47.3% | $158,579,618 | 2.551 | 9 |
| 24 | Instant Family (Paramount) | $30,723 | 324 | $95 | +79.6% | -58.7% | $66,728,227 | 4.601 | 9 |
| 25 | Destroyer (Annapurna Pictures) | $17,131 | 27 | $634 | +4.4% | +149.1% | $457,832 | 3.057 | 3 |
| 26 | Dr. Seuss' The Grinch (Universal) | $12,520 | 323 | $39 | +22.7% | -81.3% | $270,065,695 | 3.997 | 10 |
| 27 | Widows (Fox) | $10,850 | 108 | $100 | +36.6% | -30.9% | $42,253,646 | 3.418 | 9 |
| 28 | Mortal Engines (Universal) | $7,175 | 126 | $57 | +22.2% | -76.4% | $15,939,700 | 2.108 | 5 |
| 29 | Welcome to Marwen (Universal / DreamWorks) | $5,825 | 106 | $55 | +54.7% | -94.8% | $10,755,685 | 4.569 | 4 |
| 30 | Smallfoot (Warner Bros.) | $3,987 | 137 | $29 | +38.9% | -27.0% | $83,233,204 | 3.612 | 16 |
| 31 | The Nutcracker and the Four Realms (Disney) | $2,994 | 110 | $27 | +29.3% | -55.3% | $54,813,583 | 2.693 | 11 |
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