Published on May 16, 2018 at 7:00PM Pacific |

| Film (Distributor) | Weekend Gross |
Total Gross |
% Change |
Week # |
|
| 1 | Deadpool 2 (Fox) | $141.0 M | $141.0 M | NEW | 1 |
| 2 | Avengers: Infinity War (Disney) | $30.0 M | $596.7 M | -52% | 4 |
| 3 | Book Club (Paramount) | $13.8 M | $13.8 M | NEW | 1 |
| 4 | Life of the Party (Warner / New Line) | $7.7 M | $31.0 M | -57% | 2 |
| 5 | Breaking In (Universal) | $7.5 M | $30.0 M | -57% | 2 |
| 6 | Show Dogs (Global Road) | $6.5 M | $6.5 M | NEW | 1 |
| 7 | Overboard (Lionsgate / Pantelion / MGM) | $5.0 M | $37.3 M | -49% | 3 |
| 8 | A Quiet Place (Paramount) | $4.3 M | $176.4 M | -33% | 7 |
| 9 | I Feel Pretty (STXfilms) | $1.7 M | $47.1 M | -55% | 5 |
| 10 | Rampage (Warner / New Line) | $1.6 M | $92.6 M | -54% | 6 |
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